Creating Southern Fried Catfish is simple if you follow these steps:

1. Marinate the Fish: Place the catfish fillets in a bowl and cover them with buttermilk. Let sit for at least 15 minutes to soak up the flavors.
2. Prepare the Coating: In another bowl, mix together cornmeal, flour, Cajun seasoning, garlic powder, onion powder, cayenne pepper, salt, and pepper.
3. Heat the Oil: In a large skillet or frying pan, pour in oil to a depth of about 1 inch. Heat over medium-high heat until the oil is hot but not smoking.
4. Coat the Fish: Remove the catfish fillets from the buttermilk and allow excess to drip off. Dredge each fillet in the cornmeal mixture, ensuring an even coating.
5. Fry the Fish: Carefully place the coated catfish fillets in the hot oil. Fry for about 5-7 minutes on each side, or until golden brown and cooked through.
6. Drain: Once cooked, transfer the catfish to a plate lined with paper towels to drain excess oil.
7. Serve Hot: Enjoy the fish while it’s hot and crispy!

With these straightforward steps, you are on your way to making a meal that’s truly satisfying.